Jesus never promised His disciples an easy time. Quite the opposite, but they must not be deterred by opposition (Matthew 10:22) because the Lord will finally vindicate His people.
These words of Jesus seem very strong and almost offensive. But Jesus was affirming the prophecy of Micah 700 years previously: "Do not trust a neighbour; put no confidence in a friend."
Jesus was coming to the end of His pre-mission briefing to the disciples. It would be a dangerous mission because many, even in their own families, would not understand and could turn against them. (NIVUK)
Religious people can believe a number of possible lies. One: that God is so far away, or we are so bad, that it is not possible to relate with Him personally. (NIVUK)
It would be nice to think that God's servants always feel confident that working for the Lord is worthwhile. But they are all human and may doubt or be discouraged when problems overwhelm them.
Unless people know the God who has made them and want to be at peace with Him, they have no understanding of the real purpose of life, and so they play games.